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Inpatient Monitoring of Unfractionated Heparin

StatusCompleted
PhaseNot applicable
Started2024-06-26
View on ClinicalTrials.gov ↗

Amendment history

2026-09-22
Trial status changed: Enrolling by Invitation → Completed
2026-08-04
Study Status, Outcome Measures, Document Section v8
Primary completion pushed: 2026-08 → 2026-09
Completion pushed: 2026-08 → 2026-09
Secondary endpointsdetails revised at 3 of 6 entries
2026-07-17
Study Status v7
Primary completion pushed: 2026-06 → 2026-08
Completion pushed: 2026-07 → 2026-08
2026-04-14
Study Status, Study Design, Document Section v6
Enrollment reduced: 2000 → 700 participants
2026-03-27
Study Status, Outcome Measures v5
Secondary endpoints5 to 6 entries
Heparin rate changes
Show 4 earlier versions
2025-12-04
3 amendments v2-v4
3 re-verifications since 2025-06-27, no change to tracked fields
2024-07-12
Not Yet Recruiting→Enrolling by Invitation Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Enrolling by Invitation
Primary completion date2026-04→2026-06
Completion date2026-05→2026-07
Start dateestimated 2024-05→confirmed 2024-06-26
Study sitescontacts updated at 1 of 1 site
2024-03-19
Original filing
Unfractionated heparin (UFH) is the most widely used intravenous (IV) anticoagulant for treating and preventing thromboembolic disease (e.g., blood clots ). UFH must be closely monitored and adjusted in the hospital. There are two assays used to monitor UFH: 1) the activated partial thromboplastin time (PTT) and 2) the chromogenic anti-factor Xa assay (anti-Xa). This study aims to compare PTT and anti-Xa methods for monitoring UFH in a pragmatic, randomized controlled trial to determine which helps patients reach a therapeutic anticoagulation range faster.
Trial Details
NCT Number NCT06329921
Lead Sponsor Vanderbilt University Medical Center
Conditions Blood Clot, Thrombosis
Enrollment 700 participants
Start Date 2024-06-26
Primary Completion 2026-09-08 (estimated)
Study Completion 2026-09-08 (estimated)
Updated on ClinicalTrials.gov 2026-09-21