Clinical Trial

Effects of Remote Ischaemic Preconditioning in Cemented Hip Arthroplasty.

Study acronym: PRINCIPAL
Recruiting
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Record status
This record was last updated April 4, 2024 (before its estimated March 2026 completion). Its status may not reflect the trial's current state.
Summary
Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis. Cemented hip arthroplasty is mainly indicated for elderly patients with poor bone quality and multiple comorbidities. Bone cement implantation syndrome is associated with cemented hip arthroplasty and it has been shown to increase cardiovascular and renal complication and brain damage postoperatively. The aim of this project is to elucidate whether remote-ischemic preconditioning (RIPC) has multi-organ protective effect in cemented hip arthroplasty patients.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2024-03-19; most recent amendment 2024-04-03.
Status change: Not Yet Recruiting → Recruiting 2024-04-01
Trial Details
NCT Number NCT06323018
Lead Sponsor University of Tartu
Conditions Osteoarthritis, Hip, Cardiovascular Diseases, Bone Cement Implantation Syndrome, Kidney Diseases
Enrollment 200 participants
Start Date 2024-03-20
Primary Completion 2026-03 (estimated)
Study Completion 2027-03 (estimated)
Updated on ClinicalTrials.gov 2024-04-04