Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity

In this trial, the aim is to assess the clinical benefits and harms, as well as cost-effectiveness of an intensive weight loss (IWL) intervention that includes total dietary replacements, behavioural support and weight-loss medication compared with existing weight management programmes within primary care for people with severe and complex obesity.

NCT Number	NCT06321458
Lead Sponsor	Carsten Dirksen Collaborators: University of Copenhagen, University of Southern Denmark, University of Oxford, Copenhagen Trial Unit, Center for Clinical Intervention Research
Conditions	Obesity
Enrollment	600 participants
Start Date	2024-04-29
Primary Completion	2028-03 (estimated)
Study Completion	2048-12 (estimated)
Updated on ClinicalTrials.gov	2025-12-01