Effects of Hypoxic Breathwork

This project will study changes that occur during a short period of intensive daily slow-paced breathing and breath hold practice (i.e., "breathwork"). On the first and last days of the week-long practice, investigators will conduct high-density EEG recordings during breathwork to evaluate spectral power, coherence, and causality dynamics of the brain when it is naïve to breathwork and after adaptation to a breathwork practice. Breath, blood, urine, saliva, stool samples, biometric data, and sleep EEG will be collected before the start of daily breathwork practice and again after 1 week of breathwork practice to examine the effect of breathwork on full body biochemistry, molecular biology, and sleep. Investigators will also use questionnaires to assess the impact of breathwork on stress and sleep quality.

NCT Number	NCT06317259
Lead Sponsor	University of California, San Diego
Conditions	Hypoxic Breathwork With Music and Affirmative Messaging, Hypoxic Breathwork Only, Music and Affirmative Messaging
Enrollment	75 participants
Start Date	2024-06-17
Primary Completion	2027-10 (estimated)
Study Completion	2028-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-04