Systems Analysis and Improvement Approach to Prevent TB

This randomized trial uses the evidence-based Systems Analysis and Improvement Approach (SAIA) adapted for tuberculosis (SAIA-TB) to assess the comprehensive tuberculosis (TB) care cascade across 16 clinics in rural Eastern Cape, South Africa to improve patient outcomes. The aims of this study are to: * Evaluate the effectiveness of SAIA-TB use in clinics on TB cascade outcomes for TB patients and with high-risk contacts * Determine the drivers of SAIA-TB implementation success or failure across clinics The investigators hypothesize that SAIA-TB implementation will lead to a 20% increase in each of: TB screening, TB preventive treatment initiation, and TB disease treatment initiation during the 18-month intervention period.

NCT Number	NCT06314386
Lead Sponsor	Boston College Collaborators: National Institutes of Health (NIH), Boston University, University of Washington, Medical Research Council, South Africa, National Institute of Nursing Research (NINR)
Conditions	Tuberculosis, TPT, TB - Tuberculosis
Enrollment	19,560 participants
Start Date	2025-02-06
Primary Completion	2028-02-29 (estimated)
Study Completion	2029-02-28 (estimated)
Updated on ClinicalTrials.gov	2025-05-06