Clinical Trial

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

Recruiting Phase 4
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Summary
The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior cruciate ligament reconstruction surgery. The main questions it aims to answer are whether clinical outcomes, such as pain, are improved in patients who get cBMA with surgery, if there is a change in circulating markers of inflammation and what part of the cellular and molecular composition of cBMA may explain its effects.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2024-03-08; most recent amendment 2025-11-19.
Status change: Not Yet Recruiting → Recruiting 2024-11-15
Trial Details
NCT Number NCT06311513
Lead Sponsor Hospital for Special Surgery, New York
Collaborators: Emory University, Arthritis Foundation
Conditions Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee, Bone Marrow Aspirate Concentrate, ACL Injury
Enrollment 40 participants
Start Date 2024-01-22
Primary Completion 2027-12 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2025-11-20