Clinical Trial

Provocative Tests for HFpEF

Study acronym: TEST-PEF
Recruiting
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Summary
Diagnosing heart failure with preserved ejection fraction (HFpEF) in patients complaining exertional breathlessness can be challenging: diagnostic algorithms and scores have low sensitivity, and ageing-associated comorbidities can complicate the interpretation of symptoms. Thus, exercise right heart catheterization (RHC) or invasive cardiopulmonary exercise test (iCPET) have been advocated as gold-standard methods for HFpEF diagnosis. However, exercise RHC and iCPET are still not widely standardized methods, with results mainly coming from US cohorts (that may differ from Italian cohorts), and other provocative tests (e.g. non-invasive CPET, passive leg raising) may offer complementary diagnostic information.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2024-03-07.
Trial Details
NCT Number NCT06309550
Lead Sponsor Istituto Auxologico Italiano
Conditions Heart Failure With Preserved Ejection Fraction
Enrollment 500 participants
Start Date 2023-03-10
Primary Completion 2028-03 (estimated)
Study Completion 2028-03 (estimated)
Updated on ClinicalTrials.gov 2025-08-03