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Lung US for PEEP Optimization in Robotic Radical Prostatectomy or Cystectomy Patients

StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated March 18, 2026 (before its estimated April 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Minor Primary and study completion dates: Feb 2026 to Apr 2026v6
  2. Notable Primary and study completion dates: Jun 2025 to Feb 2026
    • Trial status: Recruiting to Active, Not Recruiting
    • Site details revised
    v5
  3. Notable Primary and study completion dates: Oct 2024 to Jun 2025v4
  4. Minor Primary and study completion dates: Sep 2024 to Oct 2024
    • Start date changed from estimate of Mar 2024 to Apr 1, 2024
    v3
  5. Notable Trial status: Not Yet Recruiting to Recruiting
    • Site details revised
    v2
  6. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
There is an increasing trend in the use of robotic-assisted radical prostatectomy or cystectomy (RARPC). Preventing lung atelectasis without inducing overdistention of the lung is challenging. Many studies tried to optimize PEEP titration by using methods such as dead space fraction guided and static pulmonary compliance directed techniques, or by using electrical impedance tomography. However, the use of these methods is limited by inaccuracy and the need for sophisticated devices. Bedside Lung ultrasound is fast, easy and economic technique that is gaining interest in the operating room. Ultrasound-guided PEEP titration has been used in bariatric surgeries (different position and usually shorter procedure time) and proved effective in improving oxygenation, compliance and reducing the incidence of postoperative pulmonary atelectasis and hypoxia without causing hemodynamic instability. The aim of this study is to evaluate the effectiveness of intraoperative individualized lung ultrasound-guided stepwise PEEP optimization in patients undergoing RARPC on oxygenation, intraoperative and early postoperative pulmonary complications.
Trial Details
NCT Number NCT06307704
Lead Sponsor Nazmy Edward Seif
Conditions
(from sponsor)
Prostate Cancer, Urinary Bladder Cancer, Surgery, Positive End Expiratory Pressure, Lung Ultrasound
Related terms Prostatic Neoplasms, Urinary Bladder Neoplasms
Enrollment 88 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov