Abdominal Neuroblastoma Laparoscopic Surgery Risk Factors Stratification

Surgery plays significant role in treatment of neurogenic tumors, both for benign ganglioneuroma and for high risk neuroblastoma. The world literature has accumulated large experience in laparoscopic surgery for abdominal neuroblastoma. The presence of IDRF (image-defined risk factors) and tumor size (\>4-7 cm) are considered as common contraindications for minimally invasive surgery in neuroblastoma. However, the recent studies have shown that presence of IDRF is not an absolute contraindication for laparoscopic surgery. This open-label, nonrandomized, observational, phase III evaluates role and weight of different surgical risk factors (including IDRF, tumor size, tumor localization, tumor volume/patient height ratio, previous open surgical procedures, previous chemotherapy etc.) in the laparoscopic neuroblastoma resections. The aim of this study is to create novel risk factors scoring system for laparoscopic surgery in abdominal neuroblastoma.

NCT Number	NCT06296732
Lead Sponsor	Federal Research Institute of Pediatric Hematology, Oncology and Immunology Collaborators: University Medical Center, Kazakhstan
Conditions	Neuroblastoma, Ganglioneuroma, Ganglioneuroblastoma
Enrollment	200 participants
Start Date	2023-10-19
Primary Completion	2026-10-26 (estimated)
Study Completion	2031-11-01 (estimated)
Updated on ClinicalTrials.gov	2024-05-20