Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression

Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI \> 27.5) and non-severely overweight/normoweight (BMI \< 27.5) patients affected by prostate carcinoma. ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients. iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.

NCT Number	NCT06292897
Lead Sponsor	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Collaborators: National Research Council
Conditions	Prostate Cancer, Prostate Adenocarcinoma, Prostate Neoplasm, Prostatic Neoplasm, Obesity
Enrollment	25 participants
Start Date	2023-03-20
Primary Completion	2026-09-15 (estimated)
Study Completion	2027-01-15 (estimated)
Updated on ClinicalTrials.gov	2024-03-05