Partial Cystectomy & Extended Pelvic Lymph Node Dissection With SOC Perioperative Systemic Therapy

The goal of this clinical trial is to determine if a partial cystectomy with extended pelvic lymph node removal will be effective at treating Muscle-Invasive Bladder Cancer instead of a complete cystectomy with extended pelvic lymph node removal. This clinical trial aims to determine the safety and oncologic efficacy of the intervention, and to examine patient-reported quality of life outcomes in participants. Participants will receive the standard pre-surgery treatment for approximately 4 to 6 weeks. After the pre-surgery treatment is completed, participants will undergo a partial cystectomy with extended pelvic lymph node dissection. After surgery, participants will receive adjuvant systemic therapy.

NCT Number	NCT06290687
Lead Sponsor	Case Comprehensive Cancer Center
Conditions	Malignant Neoplasm of Bladder, Muscle Invasive Bladder Carcinoma
Enrollment	40 participants
Start Date	2026-09
Primary Completion	2026-12-29 (estimated)
Study Completion	2027-12-29 (estimated)
Updated on ClinicalTrials.gov	2026-08-06