Clinical Trial

Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD

Recruiting
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Summary
Among individuals with opioid use disorder (OUD), posttraumatic stress disorder (PTSD) presents a significant clinical challenge. The prevalence of PTSD is substantially higher in individuals with OUD than in the general population, with nearly 90% reporting lifetime trauma exposure and 33% meeting diagnostic criteria for PTSD. The primary objective of this study is to evaluate the efficacy of a novel telemedicine-delivered prolonged exposure therapy protocol for improving PE attendance and reducing PTSD symptom severity in individuals with concurrent PTSD and OUD.
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2024-02-23; most recent amendment 2026-05-13.
Status change: Not Yet Recruiting → Recruiting 2024-04-11
Trial Details
NCT Number NCT06288711
Lead Sponsor University of Vermont
Collaborators: National Institute on Drug Abuse (NIDA)
Conditions Opioid Use Disorder, Posttraumatic Stress Disorder
Enrollment 135 participants
Start Date 2024-06-03
Primary Completion 2027-08-31 (estimated)
Study Completion 2027-11-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-18