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Spatial Transcriptomics in Kidney Transplantation

Study acronym: SPACE-KiT
StatusEnrolling by Invitation
PhaseNot specified
Started2024-04-03
View on ClinicalTrials.gov ↗

Amendment history

2024-04-22
Not Yet Recruiting→Enrolling by Invitation Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Enrolling by Invitation
Start dateestimated 2024-03-03→confirmed 2024-04-03
2024-03-10
Study Status, Outcome Measures v1
Secondary endpointsdetails revised at 2 of 14 entries
2024-02-24
Original filing
The study is an investigator-led, prospective, longitudinal, observational cohort study. The central hypothesis for this study is that spatial data will reveal new insights to immune cell function and local interactions within the kidney tissue to better predict important clinical outcomes. Investigators aspire to establish a prospective, longitudinal cohort to improve the diagnosis and management of kidney transplant rejection using precision pathology. By utilising new spatial technologies, the investigators aim to: * Derive a spatially resolved transcriptomic signature of kidney transplant rejection subtypes * Derive accurate transcriptomic signatures aligned with key cell types within the transplant kidney * Develop refinements to histological kidney rejection diagnostic and scoring classification * Correlate of spatial and refined biopsy scoring features to clinically important outcomes
Trial Details
NCT Number NCT06288425
Lead Sponsor Western Sydney Local Health District
Conditions Transplant Complication, Kidney Injury
Enrollment 500 participants
Start Date 2024-04-03
Primary Completion 2030-01-01 (estimated)
Study Completion 2035-01-01 (estimated)
Updated on ClinicalTrials.gov 2024-04-24