Clinical Characteristics of Small Intestinal Bacterial Overgrowth in Individuals with Abdominal Distention

Abdominal distention represents a prevalent clinical manifestation characterized by an unclear etiology and pathogenesis. This symptomatology is frequently observed in various conditions, including small intestinal bacterial overgrowth (SIBO) and abnormal orocecal transit time (OCTT). The utilization of the breath test as a non-invasive diagnostic approach has become widespread in recent years for identifying SIBO and abnormalities in OCTT. In this study, the prevalence of SIBO and OCTT irregularities in individuals presenting with abdominal distention was ascertained through the implementation of the breath test. Furthermore, the correlation between abdominal distention and SIBO/OCTT was analysed to enhance the elucidation of the underlying etiology of abdominal distention. These findings aim to offer valuable insights for refining clinical comprehension and strategies related to the diagnosis and treatment of abdominal distention.

NCT Number	NCT06285734
Lead Sponsor	Shandong University Collaborators: Qilu Hospital of Shandong University (Qingdao), Jinan Central Hospital, Zaozhuang Municipal Hospital, Weihai Municipal Hospital, Central Hospital of Zibo, Weifang People's Hospital, Dezhou Hospital Qilu Hospital of Shandong University, Binzhou Medical University, Qihe Xian Renmin Hospital
Conditions	Abdominal Distention
Enrollment	402 participants
Start Date	2024-03-01
Primary Completion	2025-08-01 (estimated)
Study Completion	2025-08-01 (estimated)
Updated on ClinicalTrials.gov	2024-12-12