Clinical Trial

Reassessment of myocardIAL Bridge TOwards PeRsOnalized Medicine

Study acronym: RIALTO PRO
Unknown
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Record status
This record was last updated July 10, 2024 (before its estimated January 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
The "RIALTO-PRO" study aims to optimize the diagnostic and therapeutic algorithm for myocardial bridge (MB) patients, testing the diagnostic value of a full invasive diagnostic procedure, and, consequently, the prognostic value of a tailored approach. the study objective is to determine the diagnostic and prognostic value of a full-physiology approach strategy versus a standard approach strategy in patients with a MB. The "RIALTO PRO" study is a randomized, multicentre, prospective, open-label, superiority trial comparing a personalised versus standard management in patients with MB. Consenting and eligible patients will be randomised 1:1 to either a "full-physiology approach", consisting of a comprehensive diagnostic algorithm aimed at unmasking the main pathophysiological mechanism of myocardial ischemia and consequently a tailored treatment, or a "standard approach", consisting of angiographic evaluation of the tunnelled segment.
Protocol Amendment History 1 change
critical Trial status changed: Recruiting → Unknown 2026-08-02
Trial Details
NCT Number NCT06281067
Lead Sponsor Azienda Ospedaliero Universitaria Maggiore della Carita
Collaborators: Università degli Studi del Piemonte Orientale Amedeo Avogadro
Conditions Myocardial Bridge
Enrollment 500 participants
Start Date 2023-12-15
Primary Completion 2026-01-01 (estimated)
Study Completion 2026-01-01 (estimated)
Updated on ClinicalTrials.gov 2024-07-10