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A Comparative Study of the Treatment of Real-world Patients With Clear Cell Carcinoma of the Ovary

StatusUnknown
PhaseNot specified
Started2023-03-01
View on ClinicalTrials.gov ↗
Record status
This record was last updated August 13, 2024 (before its estimated May 1, 2025 completion). Its status may not reflect the trial's current state.

Amendment history

2026-09-06
minor
Trial status changed: Recruiting → Unknown
2024-08-11
notable
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Unknown
Start dateestimated 2024-03-01→confirmed 2023-03-01
Study sites0→1
2024-02-23
minor
Original filing
197 trials monitored
See 2 trials at risk
1,239 trials monitored
See 74 trials at risk
The goal of this observational study is to learn about the treatment effectiveness of physician's choice of chemotherapy and the immune checkpoint inhibitor (ICI)-based therapy in patients with relapsed/refractory ovarian clear cell carcinoma (OCCC), and compare the treatment response with the phase II, single-arm clinical trial INOVA to investigate the efficacy of combinational therapy of sintilimab plus bevacizumab. The main questions it aims to answer are: * What is the efficacy of physician's choice of chemotherapy in relapsed/refractory OCCC patients in the real world? * Is ICI-based therapy more effective than physician's choice of chemotherapy in real-world for relapsed/refractory OCCC patients? * Dose the combinational regimens of sintilimab plus bevacizumab in Sintilimab Plus Bevacizumab in Recurrent/Persistent Ovarian Clear Cell Carcinoma (INOVA) trial more effective than physician's choice of chemotherapy? Participants will be respectively retrieved and extracted de-identified, longitudinal electronic health records (EHR)-derived data.
Trial Details
NCT Number NCT06279104
Lead Sponsor Tongji Hospital
Collaborators: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Henan Cancer Hospital, Qilu Hospital of Shandong University, Hubei Cancer Hospital, Anhui Provincial Cancer Hospital, Peking University Cancer Hospital & Institute, Hunan Province Tumor Hospital, First Affiliated Hospital of Suzhou Medical College, Shandong Tumor Hospital, Chongqing University Cancer Hospital, First Affiliated Hospital of Zhongshan Medical University, Peking University Shenzhen Hospital
Conditions Ovarian Clear Cell Carcinoma
Enrollment 150 participants
Start Date 2023-03-01
Primary Completion 2025-05-01 (estimated)
Study Completion 2025-05-01 (estimated)
Updated on ClinicalTrials.gov 2024-08-13