Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery

Perioperative myocardial injury and major adverse cardiovascular events (MACE) are common causes of morbidity and mortality in patients at increased cardiovascular risk undergoing non-cardiac surgery. However, research in recent years has yielded limited preventive and therapeutic measures for myocardial injury/MACE. Recent studies in patients with chronic and acute coronary artery disease have shown that colchicine administration can reduce the risk of cardiovascular events. These encouraging results in non-surgical patients ask for a similar investigation in patients undergoing major non-cardiac surgery. The aim of the proposed study is to investigate the effects of perioperative colchicine administration on the incidence of myocardial injury/MACE.

NCT Number	NCT06279000
Lead Sponsor	Cantonal Hospital of St. Gallen
Conditions	Cardiovascular Diseases, Cardiovascular Complication, Perioperative Complication, Myocardial Injury, Myocardial Injury After Noncardiac Surgery (MINS)
Enrollment	880 participants
Start Date	2025-04-20
Primary Completion	2028-03-30 (estimated)
Study Completion	2029-03-30 (estimated)
Updated on ClinicalTrials.gov	2025-04-24