Clinical Trial

Exercise for Improving Long-course Chemoradiotherapy Efficacy in People With Locally Advanced Rectal Cancer

Recruiting Early Phase 1

Record status

This record was last updated February 4, 2025 (before its estimated January 31, 2026 completion). Its status may not reflect the trial's current state.

Summary

This is a single arm feasibility study of exercise for improving long- course neoadjuvant chemoradiotherapy (NACRT) efficacy in people diagnosed with locally advanced rectal cancer. The study aims to recruit up to 30 patients from the Queen's Centre for Oncology and Haematology of Castle Hill Hospital, Cottingham, diagnosed with locally advanced rectal cancer. Consenting patients will be provided with an 11-week course of structured aerobic exercises and resistance training in the periods before, during and after their chemoradiotherapy treatment. The patients will be followed up for 6 months post long course neoadjuvant chemoradiotherapy (NACRT), with a total of 3 assessment periods.

Protocol Amendment History 5 amendments

This ClinicalTrials.gov record has been amended 5 times since 2024-02-21; most recent amendment 2025-01-30.

Status change: Not Yet Recruiting → Recruiting 2025-01-14

Trial Details

NCT Number	NCT06276686
Lead Sponsor	University of Hull Collaborators: Hull University Teaching Hospitals NHS Trust
Conditions	Locally Advanced Rectal Carcinoma
Enrollment	30 participants
Start Date	2024-12-10
Primary Completion	2026-01-31 (estimated)
Study Completion	2026-02-28 (estimated)
Updated on ClinicalTrials.gov	2025-02-04