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Influence of Timing of Implant Placement on Early Healing Molecular Events

StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 12 months later Dec 31, 2026 → Dec 31, 2027
See other at-risk trials from Queen Mary University of London

Record History

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  1. Notable Primary and study completion pushed from Dec 31, 2026 to Dec 31, 2027v8
  2. Minor Collaborator revised
    • Study description expanded, about 3 words
    v7
  3. Notable Primary completion date: Apr 30, 2026 to Dec 31, 2026
    • Study completion date: May 30, 2026 to Dec 31, 2026
    v6
  4. Minor Start date changed from estimate of Nov 2024 to Sep 26, 2024v5
  5. Notable Trial status: Not Yet Recruiting to Recruiting
    • Start date: Sep 1, 2024 to Nov 2024
    • Site details revised
    v4
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  1. Notable Start date: May 1, 2024 to Sep 1, 2024v3
  2. Minor Eligibility criteria revisedv2
  1. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Dental implants have been on the market for several years and they are routinely used to replace single/multiple missing teeth with a high success rate. However, there is still a limited number of studies comparing the influence of timing of implant placement on wound healing. In addition, there is no data available on the signaling pathways and the expression of healing biomarkers involved in the early stages of osseointegration after immediate implant placement (IP) or delayed implant placement (DP). The primary objective of this study is to describe changes in the expression of inflammatory, angiogenesis and osseous biomarkers of saliva at 1, 3, 7, 15 and 30 days and of PICF at 3, 7, 15 and 30 days after immediate implant placement (IP) compared with delayed placement (DP).
Trial Details
NCT Number NCT06276335
Lead Sponsor Queen Mary University of London
Collaborators: University of Belgrade
Conditions
(from sponsor)
Dental Implant, Healing Wound, Biomarkers, Saliva
Enrollment 24 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov