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Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI

Study acronym: MEMENTO
StatusRecruiting
PhasePhase 3
Started2024-02-22
View on ClinicalTrials.gov ↗
Record status
This record was last updated April 9, 2025 (before its estimated January 2026 completion). Its status may not reflect the trial's current state.

Amendment history

2025-04-08
Study Status v2
Re-verified, no change to tracked fields
2024-02-29
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2024-02→confirmed 2024-02-22
Study sitesdetails revised at 1 of 1 site
2024-02-16
Original filing
The goal of this clinical trial is to evaluate the role of memantine in preservation of memory and neurocognition in patients undergoing craniospinal irradiation. Participants will be randomised into two arms and the interventional arm will receive memantine along with the standard treatment. Researchers will compare the neurocognitive tests of participants in both the arms to see if memantine leads to significant preservation of memory and cognition post radiation therapy.
Trial Details
NCT Number NCT06275035
Lead Sponsor Tata Memorial Centre
Conditions Neurocognitive Dysfunction
Enrollment 101 participants
Start Date 2024-02-22
Primary Completion 2026-01 (estimated)
Study Completion 2031-01 (estimated)
Updated on ClinicalTrials.gov 2025-04-09