Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of Membranes

The goal of this study is to help identify the best antibiotic treatment for pregnant people when their water breaks prematurely (a condition abbreviated as PPROM). Current practice is to attempt to maintain the pregnancy until at least 34 weeks gestational age, when the risks of prematurity to the baby are lessened. Research shows that antibiotics help the pregnancy last longer, but there have been limited studies about which combination works best. Currently, both azithromycin and erythromycin are accepted antibiotic treatments, in addition to ampicillin and amoxicillin. Participants diagnosed with PPROM will be randomized to receive ampicillin and amoxicillin plus either azithromycin or erythromycin, in addition to the care they would normally receive. Studying these two drugs will help decide the best care for future patients with PPROM.

NCT Number	NCT06273891
Lead Sponsor	Inova Health Care Services Collaborators: Eastern Virginia Medical School
Conditions	Premature Rupture of Membrane
Enrollment	140 participants
Start Date	2024-03-08
Primary Completion	2026-05-29 (estimated)
Study Completion	2026-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-10