Clinical Trial

Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of Membranes

Study acronym: PRACET
Active, Not Recruiting Phase 3
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Summary
The goal of this study is to help identify the best antibiotic treatment for pregnant people when their water breaks prematurely (a condition abbreviated as PPROM). Current practice is to attempt to maintain the pregnancy until at least 34 weeks gestational age, when the risks of prematurity to the baby are lessened. Research shows that antibiotics help the pregnancy last longer, but there have been limited studies about which combination works best. Currently, both azithromycin and erythromycin are accepted antibiotic treatments, in addition to ampicillin and amoxicillin. Participants diagnosed with PPROM will be randomized to receive ampicillin and amoxicillin plus either azithromycin or erythromycin, in addition to the care they would normally receive. Studying these two drugs will help decide the best care for future patients with PPROM.
Trial Details
NCT Number NCT06273891
Lead Sponsor Inova Health Care Services
Collaborators: Eastern Virginia Medical School
Conditions Premature Rupture of Membrane
Enrollment 140 participants
Start Date 2024-03-08
Primary Completion 2026-05-29 (estimated)
Study Completion 2026-10-01 (estimated)
Updated on ClinicalTrials.gov 2026-06-10