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Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery

StatusRecruiting
PhaseNot applicable
Started
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Record status
This record was last updated November 18, 2025 (before its estimated February 10, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Primary completion date: Sep 30, 2025 to Feb 10, 2026
    • Study completion date: Nov 30, 2025 to Mar 30, 2026
    v9
  2. Primary completion date: Jun 30, 2025 to Sep 30, 2025
    • Study completion date: Jul 30, 2025 to Nov 30, 2025
    v8
  3. Primary completion date: Mar 30, 2025 to Jun 30, 2025
    • Study completion date: Apr 30, 2025 to Jul 30, 2025
    v7
  4. Primary completion date: Nov 30, 2024 to Mar 30, 2025
    • Study completion date: Jan 30, 2025 to Apr 30, 2025
    v6
  5. Re-verified, no change to tracked fieldsv5
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  1. Primary completion date: May 30, 2024 to Nov 30, 2024
    • Study completion date: Jun 30, 2024 to Jan 30, 2025
    v4
  2. Primary completion date: Mar 31, 2024 to May 30, 2024
    • Study completion date: May 31, 2024 to Jun 30, 2024
    v3
  3. Secondary endpoints revised (5)v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.
Trial Details
NCT Number NCT06272461
Lead Sponsor University Tunis El Manar
Conditions
(from sponsor)		 Colorectal (Colon or Rectal) Cancer, Inflammation
Related terms Colonic Neoplasms, Inflammation
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov