Clinical Trial

Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery

Recruiting
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Record status
This record was last updated November 18, 2025 (before its estimated February 10, 2026 completion). Its status may not reflect the trial's current state.
Summary
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2024-02-14; most recent amendment 2025-11-15.
Trial Details
NCT Number NCT06272461
Lead Sponsor University Tunis El Manar
Conditions Colorectal (Colon or Rectal) Cancer, Inflammation
Enrollment 50 participants
Start Date 2023-10-01
Primary Completion 2026-02-10 (estimated)
Study Completion 2026-03-30 (estimated)
Updated on ClinicalTrials.gov 2025-11-18