Tumor Microenvironment in Ovarian Cancer

A detailed understanding of molecular mechanism of cancer genesis is fundamental to develop innovative and personalized therapies. The new frontier in biomedical research is represented by organoids, a three-dimensional cell culture system obtained from a tissue fragment that accurately reproduces the essential properties of the original tissue in vitro, which could provide a valuable model for explanation of ovarian cancers pathogenesis and will allow to predict the response to a specific therapy. With this research project, we expect to generate ovarian cancer organoids to characterize in vitro interactions and molecular pathway among tumor cells, immune cells, and resident microbiota (intratumoral bacteria and/or microbial-derived molecules).

NCT Number	NCT06272240
Lead Sponsor	University of Udine
Conditions	Ovarian Cancer Stage III, Ovarian Cancer Stage IV
Enrollment	50 participants
Start Date	2024-01-02
Primary Completion	2024-07 (estimated)
Study Completion	2027-01 (estimated)
Updated on ClinicalTrials.gov	2024-02-22