The Effect of Local Application of Tranexamic Acid Versus Placebo on Postoperative Complications in Plastic Surgery

Study objective: This is a study to investigate whether applying the drug tranexamic acid (TXA) onto a surgical wound surface may affect the incidence of surgical complications such as re-bleeding needing intervention, wound complications such as infection, wound rupture or seroma, or if it may increase the risk of blood clots. Eligible patients: Patients undergoing plastic surgical procedures with wounds that would normally receive application of TXA to reduce bleeding after surgery. Study intervention: Participants will receive a single local application of study drug onto their wound surfaces at the end of surgery. Study drug will be identical looking ampoules which contain either TXA or placebo (saline). Neither participants nor study personnel will know the contents of the ampoules.

NCT Number	NCT06270407
Lead Sponsor	St. Olavs Hospital Collaborators: Smerud Medical Research International AS, Oslo University Hospital, Haraldsplass Deaconess Hospital, Helse Stavanger HF, University Hospital of North Norway, Helsinki University Central Hospital, Vejle Hospital, Bærum sykehus, Sykehuset SNR, Hamar sykehus, Tynset Sykehus
Conditions	Surgical Complication
Enrollment	3,000 participants
Start Date	2024-09-18
Primary Completion	2028-12-31 (estimated)
Study Completion	2029-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-14