2026-08-16
critical
Study Status, Contacts/Locations, Document Section v3
Trial sites expanded: 26 → 34 locations
Primary completion pushed: 2026-03-14 → 2026-12-15
Completion pushed: 2026-08-15 → 2027-03-15
2025-08-05
minor
Study Status, Arms and Interventions, Eligibility, Contacts/Locations v2
Eligibility criteria+556 characters
[...] ital admission.
HAP severity defined as a PaO2/FiO2 ratio < 200300 under invasive mechanical ventilation.
Biological systemic inflammatory response defined as CPR>≥ 150 mg/L (15 mg/dL)*
Receiving curative antimicrobial thera [...] h effective contraception for the 28 first days of the study:.
Exclusion Criteria:
Pregnant women (serum or urine test), b [...] than 48 hours.
Participation in another drug clinical trial :
testing steroids or anti-graft rejection drug or chemotherapy- radiotherapy for cancer
And / Or testing a drug regimen with a known interaction with dexamethasone,
And / Or whose implementati [...]
Study sitesdetails revised at 8 of 26 sites
2024-12-03
notable
Not Yet Recruiting→Recruiting Study Status, Eligibility, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2024-02-15→confirmed 2024-03-26
Study sites17→26
Eligibility criteria+114 characters
[...] lines (Torres et al.
Eur Respir J 2017): Association of two clinicalcriteria criteriaamong (body temperature > 38°C, leukocytosis>12000 cells per mL, leucopenia <4000 cells per mL and purulent pulmonary secretions), appearance of a new inf [...] ion).
The diagnosis of HAP can have been made outside of ICU.
Diagnosis butis done at least 48 hours after hospital admission.
SeverityHAP severity defined as a PaO2/FiO2 ratio < 200 under invasive mechanica [...] for COVID-19 infection requiring supplemental oxygen therapy a
Severe septic shock (norepinephrine > 0.4 microg/kg/min and [...] te level greater than 2 mmol/L) [...]