Clinical Trial

Oxytocin Rest to Reduce Cesarean Delivery

Study acronym: ORCA
Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated October 17, 2024 (before its estimated February 15, 2026 completion). Its status may not reflect the trial's current state.
Summary
Prolonged labor is usually managed with continuous oxytocin infusion. "Oxytocin rest" has been proposed as a strategy to resolve protracted labor in patients who have received continuous oxytocin without progress. This strategy involves discontinuing oxytocin then restarting infusion after a period of time, under the theory that washout of the oxytocin receptor will strengthen uterine contractions to improve labor progress. "Oxytocin rest" is performed on labor and delivery units across the United States. Yet, there is no randomized or prospective data to support the practice. The purpose of this study is to assess whether oxytocin rest of 60 minutes in patients with prolonged labor reduces risk for cesarean delivery.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2024-02-13.
Trial Details
NCT Number NCT06268431
Lead Sponsor Christiana Care Health Services
Conditions Prolonged Labor, Failed Induction, Labor Dystocia
Enrollment 350 participants
Start Date 2024-03-19
Primary Completion 2026-02-15 (estimated)
Study Completion 2026-03-15 (estimated)
Updated on ClinicalTrials.gov 2024-10-17