Clinical Trial

Effects of Casein Protein on Metabolism When Taken Prior to Sleep and in the Morning

Active, Not Recruiting Early Phase 1
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Summary
The purpose of this study is to investigate the effect of casein protein consumption both prior to sleep as well first thing in the morning on metabolism (increase satiety and appetite, lower resting metabolic rate, and lower blood sugar levels), when compared to nighttime protein or placebo consumption alone. Protein itself is a macronutrient that not only helps the body repair itself, and play a critical role in growth, it also aids in increasing satiety and decreasing appetite. Casein protein specifically is slow digesting dairy protein which may impact the body's metabolism for a longer period than other dairy proteins such as whey. The literature demonstrates nighttime protein ingestion prior to sleep increases metabolic rate and satiety the next morning. However, there appears to be no data on the metabolic effects of protein ingested both at night and in the morning.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2024-02-07; most recent amendment 2025-07-28.
Status change: Recruiting → Active, Not Recruiting 2024-05-29
Trial Details
NCT Number NCT06250270
Lead Sponsor Ohio University
Conditions Metabolism
Enrollment 15 participants
Start Date 2022-10-01
Primary Completion 2024-05-01 (estimated)
Study Completion 2025-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-07-30