Clinical Trial

Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

Study acronym: PREDICT

Recruiting Phase 4

Summary

This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib, or placebo. Participants will have a knee Xray, (optional) MRIs of the brain and knee, blood draws, pain sensitivity testing, and asked to fill out questionnaires. The purpose of this study is to try to predict which participants will respond to the treatment.

Protocol Amendment History 6 amendments

This ClinicalTrials.gov record has been amended 6 times since 2024-02-05; most recent amendment 2026-04-24.

Trial Details

NCT Number	NCT06245109
Lead Sponsor	Northwestern University Collaborators: Brigham and Women's Hospital
Conditions	Knee Osteoarthritis
Enrollment	180 participants
Start Date	2024-02-26
Primary Completion	2028-03-15 (estimated)
Study Completion	2028-03-15 (estimated)
Updated on ClinicalTrials.gov	2026-04-30