Energetics and Glutamate in Schizophrenia

The goal of this case-control study is to compare brain glutamate, glucose utilisation, lactate production and brain activity in healthy volunteers and people with a diagnosis of schizophrenia. It investigates the following main questions: Whether, compared to healthy volunteers, participants with schizophrenia show: 1. reduction in brain glucose utilisation 2. increased brain lactate 3. greater variability in brain glutamate Participants will be asked to have a screening visit, a MRI brain scan and a PET-MRI brain scan.

NCT Number	NCT06236048
Lead Sponsor	King's College London
Conditions	Schizophrenia
Enrollment	75 participants
Start Date	2024-03-04
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-12-01 (estimated)
Updated on ClinicalTrials.gov	2025-09-05