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Paracetamol Effect on Prostaglandins and Blood Pressure

Study acronym: PIS-PaB
StatusUnknown
PhaseNot specified
Started2025-03-01
View on ClinicalTrials.gov ↗
Record status
This record was last updated February 26, 2025 (before its estimated March 1, 2026 completion). Its status may not reflect the trial's current state.

Amendment history

2026-09-06
Trial status changed: Not Yet Recruiting → Unknown
2025-02-24
Study Status, Oversight v3
Trial statusNot Yet Recruiting→Unknown
Primary completion date2025-09-01→2026-03-01
Completion date2026-03-01→2026-09-01
Start date2024-03-01→2025-03-01
2024-02-07
Study Identification, Study Status v2
Study title-1 characters
Paracetamol EfffectEffect on Prostaglandins and Blood Pressure
2024-01-31
Study Identification, Study Status, Outcome Measures v1
Secondary endpointsdetails revised at 1 of 1 entry
Study title-30 characters
Paracetamol ImpactEfffect Study:on Prostaglandin SynthesisProstaglandins and Blood Pressure Effects (PIS-PaB)
2024-01-30
Original filing
This research program aims to investigate the influence of paracetamol on blood pressure and the cyclooxygenase (COX) - prostaglandine (PG) pathway in patients with pain. Through an observational pilot study, we will use advanced LC/ESI-MS/MS methodology to analyze the COX-OG pathway in plasma and urine. The study will assess the effects of paracetamol compared to ibuprofen, considering different types of pain. The primary focus is to understand the changes in blood pressure and the COX-PG pathway upon initiation or discontinuation of paracetamol, with safety analysis as a secondary consideration.
Trial Details
NCT Number NCT06235320
Lead Sponsor Charite University, Berlin, Germany
Conditions Pain
Enrollment 72 participants
Start Date 2025-03-01
Primary Completion 2026-03-01 (estimated)
Study Completion 2026-09-01 (estimated)
Updated on ClinicalTrials.gov 2025-02-26