Clinical Trial

Effect of Diluent Volume on Colistin Inhalation Therapy

Recruiting
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Record status
This record was last updated February 27, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
The aim of this study is to investigate the impact of different diluent volumes for the same dosage of colistin in mechanically ventilated respiratory patients receiving colistin inhalation therapy. The study aims to determine whether the diluent volume has an effect on clinical outcomes, including ICU length of stay, total hospitalization duration, duration of respiratory support within 28 days, mortality rates within 28 days and 90 days, as well as analyze the pharmacokinetic profile of colistin in blood and bronchoalveolar lavage fluid. Additionally, the study will evaluate the incidence of nebulizer malfunctions and blockages. The findings of this research will help identify the optimal diluent volume for colistin inhalation therapy in clinical practice.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2024-01-21; most recent amendment 2026-02-25.
Status change: Not Yet Recruiting → Recruiting 2024-03-11
Trial Details
NCT Number NCT06230614
Lead Sponsor Fu Jen Catholic University
Conditions Inhalation Pneumonia
Enrollment 60 participants
Start Date 2024-03-10
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-27