Cognition After OSA Treatment Among Native American People (CATNAP)

This research project will develop and implement a motivational interviewing and electronic messaging intervention to address obstructive sleep apnea (OSA), positive airway pressure (PAP) adherence, and risk of Alzheimer's disease and related dementias in American Indians. The project will work with American Indian Elders, aged 50 years and older, from three Northern Plains Reservations and surrounding communities. A total of 300 American Indian elders with a confirmed OSA diagnosis and prescribed PAP therapy will be randomized to receive usual care consisting of PAP therapy alone (control condition) or usual care plus the culturally informed CATNAP MI component (intervention condition).

NCT Number	NCT06227572
Lead Sponsor	Washington State University Collaborators: Missouri Breaks Industries Research, Inc., University of Washington, University of Minnesota
Conditions	Obstructive Sleep Apnea, Cognitive Change
Enrollment	140 participants
Start Date	2025-02-06
Primary Completion	2027-12-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-09