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NCT06218485 · ClinicalTrials.gov record · last posted 2026-08-27

FFR Versus IVUS With Angiography-Derived FFR for Clinical Outcomes in Patients With Coronary Artery Disease

Study acronym: FLAVOUR III
StatusActive, Not Recruiting
PhaseNot applicable
Started2024-03-13
View on ClinicalTrials.gov ↗
from the ClinicalTrials.gov record
To compare the clinical outcomes of fractional flow reserve (FFR)-guided strategy versus intravascular ultrasound (IVUS)-guided stent implantation after angiography-derived FFR-based decision-making.

Protocol amendment history 5 changes detected by DataLookout

2026-08-28
notable
Enrollment closed, study ongoing
2026-08-28
minor
Trial sites expanded: 25 → 32 locations
2026-08-28
critical
Primary completion pushed: 2027-12-01 → 2028-09-01
2026-08-28
minor
Completion pushed: 2029-12-01 → 2031-09-01
2026-08-09
notable
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
WasSecond Affiliated Hospital, School of Medicine, Zhejiang University
NowSecond Affiliated Hospital, Zhejiang University, School of Medicine
Trial Details
NCT Number NCT06218485
Lead Sponsor Second Affiliated Hospital, Zhejiang University, School of Medicine
Collaborators: Seoul National University Hospital, Peking University Third Hospital, Second Affiliated Hospital of Shantou University Medical College, The First Affiliated Hospital of Nanchang University, The Fourth People's Hospital of Jinan, Jinhua Central Hospital, The Affiliated Hospital of Hangzhou Normal University, Changxing People's Hospital, First Affiliated Hospital of Wenzhou Medical University, The Affiliated Hospital of Medical College, Ningbo University, Keimyung University Dongsan Medical Center, Inje University Ilsan Paik Hospital, Ulsan University Hospital, Uijeongbu Eulji University Hospital, Inje University Haeundae Paik Hospital, Chonnam National University Hospital, Ningbo Medical Center Lihuili Hospital, Jining First People's Hospital, Huzhou Central Hospital, Zhejiang Hospital, First People's Hospital of Hangzhou, Wuhan Aisa Heart Hospital, The Southwest Hospital of Army Medical University, Sir Run Run Shaw Hospital, Ganzhou People's Hospital, Jiangxi Province, Fifth Affiliated Hospital, Sun Yat-Sen University, Xiangya Hospital of Central South University, Shanxi Cardiovascular Hosipital, First Affiliated Hospital of Guangxi Medical University, Renmin Hospital of Wuhan University, Second Affiliated Hospital of Nanchang University
Conditions Coronary Artery Disease
Enrollment 1,942 participants
Start Date 2024-03-13
Primary Completion 2028-09-01 (estimated)
Study Completion 2031-09-01 (estimated)
Updated on ClinicalTrials.gov 2026-08-27