Vasopressin for Septic Shock Pragmatic Trial

Life-threatening low blood pressure due to a serious infection is called "septic shock." Septic shock is treated with vasopressors, medications that raise blood pressure. Sometimes first-line vasopressors are inadequate, prompting addition of a second-line vasopressor called vasopressin. However, the threshold at which to start vasopressin remains unclear. This pragmatic, cluster-randomized, cluster-crossover trial will evaluate two different strategies for septic shock treatment commonly used in current practice, comparing a lower versus a higher threshold for adding vasopressin to first-line vasopressors.

NCT Number	NCT06217562
Lead Sponsor	Intermountain Health Care, Inc. Collaborators: University of Utah
Conditions	Septic Shock
Enrollment	3,959 participants
Start Date	2024-02-01
Primary Completion	2026-02-17 (estimated)
Study Completion	2026-06-06 (estimated)
Updated on ClinicalTrials.gov	2026-08-03