Escitalopram in Asthma Patients With Frequent Exacerbation

Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), such as escitalopram are widely used for mood and anxiety disorders. However, they have also been explored, with promising findings, for a variety of disorders outside of psychiatry. Clinical studies of SSRIs in depressed people with asthma were associated with decreased asthma exacerbations and improvement in asthma control. In this study, the number of asthma exacerbations will be assessed as the primary outcome measure in patients using escitalopram vs. placebo.

NCT Number	NCT06216535
Lead Sponsor	University of Texas Southwestern Medical Center Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Conditions	Asthma
Enrollment	105 participants
Start Date	2025-05-19
Primary Completion	2028-12-01 (estimated)
Study Completion	2029-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-26