EMDR Versus Imagery Rescripting for Trauma-Related Intrusions

The goal of this clinical trial is to investigate the effectiveness and mechanisms of action of trauma treatments in a sample of patients meeting criteria for posttraumatic stress disorder (PTSD), unipolar depression, or both disorders. The main questions it aims to answer are: * which first line treatment (Eye Movement Desensitization and Reprocessing \[EMDR\] vs. Imaginary Rescripting \[IR\]) works better for intrusive experiences in patients with PTSD, patients with a depression, and patients who meet criteria for both diagnoses. * which mechanisms of action cause the treatment effects. Participants will * be randomly assigned to a standard treatment of EMDR or IR * complete daily questionnaires measuring the outcome measures two weeks before the start of their treatment, during their EMDR or IR treatment, and for one month after their treatment. * complete questionnaires measuring the outcome measures and secondary outcome measures at pre-intervention, post-treatment (i.e., 4 weeks after the last intervention session, at the end of the withdrawal phase), and at 6-month follow-up.

NCT Number	NCT06215313
Lead Sponsor	Geestelijke Gezondheidszorg Eindhoven (GGzE) Collaborators: Maastricht University
Conditions	Stress Disorders, Post-Traumatic, Depression
Enrollment	42 participants
Start Date	2025-01-28
Primary Completion	2026-06 (estimated)
Study Completion	2026-11 (estimated)
Updated on ClinicalTrials.gov	2025-03-12