Clinical Trial

Prospective Validation of Adaptive Radiotherapy (ART) in Patients With Head and Neck Tumors

Study acronym: ART in HNT

Recruiting

Record status

This record was last updated September 27, 2024 (before its estimated December 15, 2024 completion). Its status may not reflect the trial's current state.

Summary

Adaptive radiotherapy (ART) includes image-guided radiotherapy (IGRT) and also offers further possibilities for plan adaptation. A particularly high benefit can be expected for patients in whom the clinical target volume (CTV) can show a significant change in shape from fraction to fraction due to anatomical deviations. The shape and position constancy of the CTV during the course of the series is examined in this trial. Dosimetric disadvantages of this type have not been reported so far. The aim of this study is to identify patients who benefit from ART at an early stage and to select them for this method, and then to continue to offer ART to this patient group. If a relevant reduction in the minimum planning target volume (PTV) margins with ART compared to IGRT is demonstrated in this study, patients could be treated with ART.

Protocol Amendment History 3 amendments

This ClinicalTrials.gov record has been amended 3 times since 2024-01-10; most recent amendment 2024-09-25.

Trial Details

NCT Number	NCT06214611
Lead Sponsor	University Hospital, Essen
Conditions	Head and Neck Cancer, Adaptive Radiotherapy, Radiation, Optimized Treatment, Protection of Organs at Risk, Dysphagia Reduction
Enrollment	50 participants
Start Date	2023-11-15
Primary Completion	2024-12-15 (estimated)
Study Completion	2027-12-15 (estimated)
Updated on ClinicalTrials.gov	2024-09-27