Radiation Therapy in Unresectable Gall Bladder Cancer

The goal of this clinical trial is to compare two treatment regimes, namely, systemic therapy (chemotherapy and/or immunotherapy) alone vs. systemic therapy and radiation therapy in patients with inoperable but localized gallbladder cancer. The main questions it aims to answer are: * Whether adding radiation therapy to systemic therapy improves overall survival? * What are the effects on other endpoints like cancer-free intervals, side effects, and quality of life? Participants will be randomly assigned to one of the two treatment regimes mentioned earlier by a computer-based program. Researchers will compare survival and quality of life outcomes between the two groups.

NCT Number	NCT06214572
Lead Sponsor	Tata Memorial Centre
Conditions	Gall Bladder Cancer
Enrollment	249 participants
Start Date	2024-03-07
Primary Completion	2029-07-21 (estimated)
Study Completion	2029-07-21 (estimated)
Updated on ClinicalTrials.gov	2025-04-11