Effects of Individualized Training to Reduce Fatigue in Patients With Newly and Advanced Diagnosed Multiple Sclerosis

Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system. It is characterized by complex and heterogeneous symptoms. Chronic fatigue is the most reported symptom in MS patients (80%). Current pharmacological treatments for MS patients reduce the number of relapses and their severity but do not improve symptoms such as fatigue. Physical activity is a therapy that helps reduce this fatigue, in addition to improving muscular and cardiorespiratory functions. However, the results are not optimal because MS patients remain less active than the general population. The improvement of the benefits of exercise therapy could therefore be based on three approaches: personalization of the training program, home practice and early initiation.

NCT Number	NCT06201026
Lead Sponsor	Centre Hospitalier Universitaire de Saint Etienne
Conditions	Sclerosis, Fatigue
Enrollment	96 participants
Start Date	2023-09-12
Primary Completion	2025-07-01 (estimated)
Study Completion	2025-09-15 (estimated)
Updated on ClinicalTrials.gov	2024-10-23