Clinical Trial

Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer

Study acronym: CIRCULATE PAC
Recruiting Phase 3
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Summary
Phase III multicentric, open-label, randomized study The main objective is to assess the efficacy on time to disease recurrence (TTR) of treating minimal residual disease diagnosed by the presence of ctDNA after full treatment (surgery + chemotherapy) in stage III or high-risk stage II colon or upper rectum adenocarcinoma
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2024-01-08.
Status change: Not Yet Recruiting → Recruiting 2026-05-19
Trial Details
NCT Number NCT06197425
Lead Sponsor Centre Hospitalier Universitaire Dijon
Conditions Colon or Upper Rectum Adenocarcinoma
Enrollment 1,660 participants
Start Date 2026-05-07
Primary Completion 2032-05 (estimated)
Study Completion 2032-05 (estimated)
Updated on ClinicalTrials.gov 2026-05-22