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Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder

StatusRecruiting
PhaseNot applicable
Started
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Record status
This record was last updated January 3, 2024 (before its estimated July 1, 2025 completion). Its status may not reflect the trial's current state.

Record History

  1. Study First Submitted
This study aims to explore the effect of 5-Hz rTMS over the left dorsolateral prefrontal cortex on the BDNF, craving and cognitive function. This study will be longitudinal, with a short-term double-blind placebo-controlled phase consisting of 20 rTMS sessions and a long-term phase, consisting of 2 weekly sessions for 12 weeks. Participants will be clinically assessed pre-treatment (T0), after 20-sessions phase (T1) and after 12-weeks phase (T2) by an interview about psychiatric symptoms. Also, blood will be obtained in the same T0, T1 and T2 to peripheral levels of BDNF determination. Cognitive state will be measured at the same time-points (T0, T1, T2) by paper-pencil and computerized neuropsychological assessment. Researchers will compare active rTMS versus placebo 5 Hz-rTMS on described variables. Additionally, a comparative group (without rTMS intervention) will be included to equivalently measure described variables during periods without cocaine consumption.
Trial Details
NCT Number NCT06189690
Lead Sponsor Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Collaborators: National Council of Science and Technology, Mexico
Conditions
(from sponsor)		 Cocaine Dependence
Related terms Cocaine-Related Disorders
Enrollment 102 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov