Clinical Trial

Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding

Study acronym: TREET
Recruiting
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Summary
A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus conventional endoscopic hemostatic therapy in patients presenting with acute overt gastrointestinal bleeding which is found at endoscopy to be due to one of the following sources: a gastric or duodenal ulcer with active bleeding (spurting or oozing) or a non-bleeding visible vessel; an esophageal, gastric or duodenal tumor with active bleeding or a non-bleeding visible vessel; a gastric or duodenal Dieulafoy lesion with active bleeding or a non-bleeding visible vessel; or an actively bleeding Mallory-Weiss tear.
Protocol Amendment History 12 amendments
This ClinicalTrials.gov record has been amended 12 times since 2023-12-18; most recent amendment 2026-06-17.
Status change: Not Yet Recruiting → Recruiting 2024-08-12
Trial Details
NCT Number NCT06188585
Lead Sponsor Medtronic - MITG
Collaborators: North American Science Associates Ltd.
Conditions Acute Gastrointestinal Bleeding
Enrollment 278 participants
Start Date 2024-06-21
Primary Completion 2029-08 (estimated)
Study Completion 2029-09 (estimated)
Updated on ClinicalTrials.gov 2026-06-22