EEG-fMRI Experiments During Anesthesia Induction With Propofol

This observational study aims to investigate healthy cortical and subcortical neural processes involved in generating intrinsic alpha oscillations during induction of general anesthesia with propofol. To do this, the investigators have designed a simultaneous electroencephalogram (EEG)- MRI (functional MRI and Spectroscopy) experiment with a visual stimulation paradigm that addresses the subject's specific intrinsic alpha rhythm during anesthesia and wakefulness. The main question it aims to answer is: could the investigators address the alpha oscillation system of the healthy brain with external stimulation during anesthesia? This experiment could lead to a better understanding of the mechanisms underlying the generation of alpha oscillations. It could open new doors to diagnostic and treatment options for diseases where alpha oscillations, such as post-operative delirium, seem to be affected.

NCT Number	NCT06179719
Lead Sponsor	Technical University of Munich
Conditions	Anesthesia
Enrollment	35 participants
Start Date	2023-09-10
Primary Completion	2024-09-10 (estimated)
Study Completion	2026-09-10 (estimated)
Updated on ClinicalTrials.gov	2023-12-22