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Mechanisms of Exposure Therapy for OCD

StatusRecruiting
PhaseNot applicable
Started2024-10-16
View on ClinicalTrials.gov ↗

Amendment history

2026-06-24
minor
Study Status, Contacts/Locations v4
Study sitescontacts updated at 1 of 2 sites
2025-12-30
minor
Study Status, Contacts/Locations, IPDSharing v3
Study sitescontacts updated at 2 of 2 sites
2024-10-30
notable
Not Yet Recruiting→Recruiting Study Status, Oversight, Contacts/Locations, IPDSharing v2
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2024-10→confirmed 2024-10-16
Study sites0→2
2024-06-07
minor
Study Status v1
Start date2024-04→2024-10
2023-12-13
minor
Original filing
53 trials monitored
See 1 trial at risk
Exposure therapy is the most effective treatment available for obsessive compulsive disorder, yet up to 50% of patients do not recover because the mechanisms underlying successful response are poorly understood, leading to significant variability in how clinicians conduct exposure therapy. The main purpose of this study is to determine which target mechanisms are most critical to engage in real-world exposure sessions to produce good treatment outcomes. Adult participants (N = 400) with Obsessive Compulsive Disorder (OCD) receiving exposure therapy from two sites (McLean Hospital, San Diego State University) across the continuum of care (outpatient, partial hospital, residential) will complete baseline clinical and demographic measures as well as weekly symptom reports. The project will measure exposure mechanisms across three levels of analysis (self-report, observer-rated behavior, physiology) during each exposure session. Mechanisms assessed will include a broad range of variables based on both habituation and inhibitory learning models of exposure. Self-report and observer-rated mechanisms will be measured with the Exposure Feedback Form, created and piloted by the study team. Physiological mechanisms will include skin conductance response, heart rate, and heart rate variability measured with a wristwatch. The current study will determine (1) which exposure mechanisms lead to favorable clinical outcomes, and (2) what makes a good exposure for whom. Results of this study have the potential to improve personalized care for the many patients who do not remit following exposure therapy for OCD.
Trial Details
NCT Number NCT06173752
Lead Sponsor Mclean Hospital
Conditions Obsessive-Compulsive Disorder
Enrollment 400 participants
Start Date 2024-10-16
Primary Completion 2029-04 (estimated)
Study Completion 2029-04 (estimated)
Updated on ClinicalTrials.gov 2026-06-25