Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection

In this Dutch multicenter clinical trial, patients with a staphylococcal prosthetic joint infection, will, in the oral antibiotic treatment phase, be randomized between clindamycin monotherapy and rifampicin / levofloxacin combination therapy. The clinical endpoint will be treatment success one year after finishing antimicrobial treatment.

NCT Number	NCT06172010
Lead Sponsor	Leiden University Medical Center Collaborators: University Medical Center Groningen, Onze Lieve Vrouwe Gasthuis, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Frisius Medisch Centrum, Isala, Martini Hospital Groningen, Radboud University Medical Center, Sint Maartenskliniek, Elisabeth-TweeSteden Ziekenhuis, Erasmus Medical Center, Alrijne Hospital, Spaarne Gasthuis, Reinier Haga Orthopedisch Centrum, Tergooi Hospital, Rijnstate Hospital
Conditions	Prosthetic-joint Infection, Infection Hip, Infection; Knee, Joint
Enrollment	316 participants
Start Date	2023-04-01
Primary Completion	2027-03 (estimated)
Study Completion	2028-03 (estimated)
Updated on ClinicalTrials.gov	2023-12-15