Developing Allogeneic Musculoskeletal Therapies

The goal of this observational study is to analyse the cartilage and bone forming potential of cells isolated from the tissues of patients undergoing surgery for the treatment of polydactyly, hip dislocation and from other bio-banked cartilage tissues. The main question it aims to answer is: Which of the following tissues from polydactyly digit, iliac apophysis or other bio-banked cartilage produce better cartilage in vitro and in vivo? Participants receiving digit amputation surgery for treatment of polydactyly will be asked to donate the associated waste tissue whilst participants receiving surgery to treat a dislocated hip will be asked to donate an extra small piece of cartilage tissue (approximately 1 gram) from the iliac apophysis. Other tissues for the study will be obtained from those donated to biobanks.

NCT Number	NCT06167928
Lead Sponsor	Keele University Collaborators: Alder Hey Children's NHS Foundation Trust, Birmingham Women's and Children's NHS Foundation Trust, Norfolk and Norwich University Hospitals NHS Foundation Trust, Royal National Orthopaedic Hospital NHS Trust, Scottish National Blood Transfusion Service, NHS Blood and Transplant, University of Birmingham, Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust, The Royal Orthopaedic Hospital NHS Trust
Conditions	Osteoarthritis
Enrollment	325 participants
Start Date	2018-10-08
Primary Completion	2028-06-30 (estimated)
Study Completion	2037-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-11