Clinical Trial

Hyaluronan-enriched Medium and Euploid Blastocyst Transfers

Study acronym: GluePloid
Recruiting
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Summary
It has been proposed that enriching transfer media with hyaluronan (EmbryoGlue medium) improves pregnancy outcomes compared with media containing lower concentrations of this molecule. However, none of previous studies included preimplantation genetic testing for aneuploidy (PGT-A) embryos. In order to investigate the impact of this hyaluronan-enriched on pregnancy outcomes, it is essential to evaluate its efficacy on euploid-only embryo transfers. The aim of the present study is to evaluate whether a short period of exposure of euploid blastocysts to EmbryoGlue prior to and during transfer positively impact on pregnancy outcomes of frozen embryo transfer (FET) cycles.
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2023-12-08; most recent amendment 2026-06-22.
Status change: Not Yet Recruiting → Recruiting 2024-01-30
Trial Details
NCT Number NCT06165367
Lead Sponsor ART Fertility Clinics LLC
Conditions Infertility, Implantation Rate, Clinical Pregnancy Rate, Live Birth Rate, Blastocysts, FET
Enrollment 783 participants
Start Date 2024-01-15
Primary Completion 2026-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-06-25