Clinical Trial

Follow-up of Spanish Prospective Asthma and Nasal Polyposis Registry

Study acronym: MEGA
Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated March 30, 2026 (before its estimated June 2, 2026 completion). Its status may not reflect the trial's current state.
Summary
Primary objective \- To study the stability of different phenotypes and endotypes of asthma at 3, 5, and 7 years of follow-up and - in MEGA COHORT and in patients on biologic treatment Secondary objective(s) * To study biomarkers variation post-treatment in patients with and without Nasal Polyposis * To demonstrate the existence of different subtypes of eosinophils that may be phenotypically and functionally heterogeneous * To increase the number of patients in the cohort on biologic treatment to reach at least 900 (400 over the current cohort).
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-12-01; most recent amendment 2026-03-25.
Status change: Not Yet Recruiting → Recruiting 2026-03-25
Trial Details
NCT Number NCT06163807
Lead Sponsor Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Collaborators: Sanofi
Conditions Chronic Asthma
Enrollment 1,200 participants
Start Date 2025-02-01
Primary Completion 2026-06-02 (estimated)
Study Completion 2026-06-02 (estimated)
Updated on ClinicalTrials.gov 2026-03-30