Brain Network Analysis of Anesthesia Characteristics in Patients With pDoC Based on PSG

The goal of this prospective, exploratory and observational study is to learn about in healthy volunteers and patients with prolonged disorders of consciousness(pDoC). The main questions it aims to answer are: 1. Observe the similarities and differences of polysomnography between pDoC patients and healthy volunteers, and analyze the characteristic brain network changes based on polysomnography 2. To observe the similarities and differences of polysomnography in pDoC patients before and after Insertion of spinal cord electric stimulator under general anesthesia,and analyze the changes of anesthesia characteristic brain network in patients with consciousness disorders based on polysomnography. 3. To observe the similarities and differences of polysomnography in pDoC patients before and after spinal cord stimulation,and analyze the characteristic changes of brain network after spinal cord stimulation. We will record the 8h polysomnography of healthy volunteers,record the polysomnography of DOC patients before and 24 hours after operation;and record the 24h polysomnography of patients with spinal cord electric stimulator.

NCT Number	NCT06157008
Lead Sponsor	Beijing Tiantan Hospital
Conditions	Disorders of Consciousness
Enrollment	60 participants
Start Date	2023-01-11
Primary Completion	2025-06-01 (estimated)
Study Completion	2025-06-01 (estimated)
Updated on ClinicalTrials.gov	2024-08-01