Rescue Endovascular Therapy for Progressive Acute Mild Ischemic Stroke With Large Vascular Occlusion

Endovascular therapy (EVT) added on best medical management is currently recommended in acute large vascular occlusion (LVO) stroke patients with National Institutes of Health Stroke Scale (NIHSS) score \>5. Thus, a sizeable fraction of patients with a minor stroke that do not undergo cerebrovascular screening may experience an early neurological deterioration (END) due to LVO, possibly leading to poor long-term functional outcome. However, whether these patients may still benefit from a rescue EVT is unknown, especially in a late window (\>24 hours). In this study, the investigators assume that best medical management plus EVT might be superior than best medical management alone in a late window for minor stroke patients who have experienced an LVO and END. The primary objective of the study was to establish the safety and efficacy of EVT in a late window for minor stroke patients in the anterior circulation who experienced an LVO and END.

NCT Number	NCT06155032
Lead Sponsor	First Affiliated Hospital of Wannan Medical College Collaborators: The First Affiliated Hospital of Anhui Medical University, Xiangtan Central Hospital, The First Affiliated Hospital of Hainan Medical University, Huang Shan People's Hospital, Fuyang people's hospital, Linyi People's Hospital, Jiujiang No.1 People's Hospital, Taihe Hospital
Conditions	Stroke, Ischemic, Cerebrovascular; Disorder, Occlusive
Enrollment	272 participants
Start Date	2024-01-04
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-03-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-30